My talk on layer-fMRI in the Brain Space Initiative Speaker Series.

The BrainSpace Initiative is an outreach program that allows researchers to present their work, currently on non-invasive technique. It is also a meeting space to discuss papers and issues. I was invited to both be a member of the advisory committee and to give a talk. I decided to present a talk on all the work on layer fMRI has come out of my lab over the past 4 years. Here it is:

My brain space initiative talk

Layer fMRI, requiring high field, advanced pulse sequences, and sophisticated processing methods, has emerged in the last decade. The rate of layer fMRI papers published has grown sharply as the delineation of mesoscopic scale functional organization has shown success in providing insight into human brain processing. Layer fMRI promises to move beyond being able to simply identify where and when activation is taking place as inferences made from the activation depth in the cortex will provide detailed directional feedforward and feedback related activity. This new knowledge promises to bridge invasive measures and those typically carried out on humans. In this talk, I will describe the challenges in achieving laminar functional specificity as well as possible approaches to data analysis for both activation studies and resting state connectivity. I will highlight our work demonstrating task-related laminar modulation of primary sensory and motor systems as well as layer-specific activation in dorsal lateral prefrontal cortex with a working memory task. Lastly, I will present recent work demonstrating cortical hierarchy in visual cortex using resting state connectivity laminar profiles.

Author: Peter Bandettini

Peter Bandettini has been working in functional brain imaging since he started his Ph.D. thesis work on fMRI method development in 1991 in the Biophysics Department at the Medical College of Wisconsin (MCW). After completing a post doc at Massachusetts General Hospital in 1996 and a brief Assistant Professorship at MCW, he became Chief of Functional Imaging Methods and Director of the Functional MRI Facility at the National Institutes of Health in Bethesda, MD. He was Editor-In-Chief of NeuroImage from 2011-2017 and has been active in both the MRI community (International Society for Magnetic Resonance in Medicine) and the Brain Imaging Methods community (Organization for Human Brain Mapping). All his views and posts are his own.

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